| 1 | Fidelity Investments Charitable Gift Fund | MA | 2024 | $15.3 billion$15,307,491,635 | not itemized | $86.3 billion$86,270,322,515 | 17.7% |
| 2 | Donor Advised Charitable Giving | CO | 2024 | $8.9 billion$8,872,852,963 | not itemized | $47.5 billion$47,548,536,893 | 18.7% |
| 3 | Guerreras Latinas | OR | 2024 | $8.2 billion$8,179,781,796 | not itemized | $0$0 | not applicable |
| 4 | Gates Foundation Trust | WA | 2024 | $8.1 billion$8,096,000,000 | 2 | $77.6 billion$77,564,446,975 | 10.4% |
| 5 | National Philanthropic Tr | PA | 2024 | $6.4 billion$6,415,072,479 | not itemized | $56.1 billion$56,096,033,883 | 11.4% |
| 6 | Global Fund to Fight AIDS Tuberculosis and Malaria | not reported | 2024 | $6.2 billion$6,217,247,903 | not itemized | $7.5 billion$7,507,202,758 | 82.8% |
| 7 | Gates Foundation | WA | 2024 | $5.9 billion$5,856,756,578 | 4,974 | $78.7 billion$78,673,465,696 | 7.4% |
| 8 | Feeding America | IL | 2024 | $4.8 billion$4,771,873,654 | not itemized | $572.5 million$572,495,646 | 833.5% |
| 9 | Astrazeneca Patient Assistance Organization | DE | 2024 | $4.6 billion$4,589,156,843 | not itemized | $0$0 | not applicable |
| 10 | Sanofi-Aventis Patient Assistance Foundation | NJ | 2024 | $4.1 billion$4,149,829,881 | 1 | $0$0 | not applicable |
| 11 | Lilly Endowment Inc | IN | 2025 | $3.9 billion$3,864,431,404 | 2,285 | $105.9 billion$105,894,116,636 | 3.6% |
| 12 | Genentech Patient Foundation | CA | 2024 | $3.5 billion$3,513,726,500 | 1 | $424.1 million$424,094,878 | 828.5% |
| 13 | Vanguard Charitable Endowment Program | PA | 2024 | $3.5 billion$3,503,325,979 | not itemized | $27.3 billion$27,313,445,525 | 12.8% |
| 14 | Silicon Valley Community Foundation | CA | 2024 | $3.3 billion$3,326,495,992 | not itemized | $12.3 billion$12,299,698,780 | 27.0% |
| 15 | GOOD360 | VA | 2024 | $3.3 billion$3,295,725,303 | not itemized | $108.1 million$108,126,257 | 3,048.0% |
| 16 | Novartis Patient Assistance Foundation | NJ | 2024 | $3.1 billion$3,097,009,871 | 1 | $382.9 million$382,899,147 | 808.8% |
| 17 | GS Donor Advised Philanthropy Fund for Wealth Management Inc | NY | 2024 | $3.1 billion$3,082,130,420 | not itemized | $12.7 billion$12,737,589,000 | 24.2% |
| 18 | GAVI Alliance | DC | 2024 | $2.9 billion$2,912,788,961 | not itemized | $9.5 billion$9,505,640,020 | 30.6% |
| 19 | Bristol-Myers Squibb Patient Assistance Foundation Inc | NJ | 2024 | $2.7 billion$2,658,494,866 | 1 | $230.7 million$230,714,652 | 1,152.3% |
| 20 | National Christian Charitable Foundation | GA | 2024 | $2.6 billion$2,604,923,993 | not itemized | $6.1 billion$6,064,060,160 | 43.0% |
| 21 | American Online Giving Foundation Inc | DE | 2025 | $2.3 billion$2,324,264,081 | not itemized | $445.3 million$445,317,505 | 521.9% |
| 22 | International Olympic Committee | not reported | 2024 | $2.3 billion$2,295,751,344 | not itemized | $4.7 billion$4,735,675,750 | 48.5% |
| 23 | The Wellcome Trust | not reported | 2024 | $2.0 billion$2,032,579,851 | not itemized | $57.9 billion$57,932,370,800 | 3.5% |
| 24 | Direct Relief | CA | 2024 | $2.0 billion$2,002,150,217 | not itemized | $1.3 billion$1,292,290,030 | 154.9% |
| 25 | Boehringer Ingelheim Cares Foundation Inc | CT | 2025 | $2.0 billion$1,988,478,993 | 1 | $303.0 million$302,951,448 | 656.4% |
| 26 | Gothic Corporation | NC | 2024 | $2.0 billion$1,963,772,469 | not itemized | $9.0 billion$8,960,129,815 | 21.9% |
| 27 | Merck Patient Assistance Program Inc | NJ | 2024 | $1.9 billion$1,911,974,863 | 1 | $26.4 million$26,439,841 | 7,231.4% |
| 28 | American Lebanese Syrian Assoc Char Inc | TN | 2024 | $1.9 billion$1,878,044,650 | not itemized | $10.9 billion$10,928,116,611 | 17.2% |
| 29 | NYU Langone Hospitals | NY | 2024 | $1.8 billion$1,826,026,116 | not itemized | $13.1 billion$13,091,045,206 | 13.9% |
| 30 | Americares Foundation Inc | CT | 2024 | $1.8 billion$1,756,724,514 | not itemized | $372.5 million$372,542,711 | 471.5% |
| 31 | Mayo Clinic Group Return | MN | 2024 | $1.7 billion$1,672,735,071 | not itemized | $17.9 billion$17,859,698,606 | 9.4% |
| 32 | Morgan Stanley Global Impact Funding Trust Inc | NY | 2024 | $1.6 billion$1,649,055,373 | not itemized | $9.1 billion$9,109,107,748 | 18.1% |
| 33 | Conference on Jewish Material Claims Against Germany | NY | 2024 | $1.5 billion$1,543,826,336 | not itemized | $784.5 million$784,520,458 | 196.8% |
| 34 | Pfizer Patient Assistance Foundation Inc | NY | 2024 | $1.5 billion$1,480,409,944 | 45 | $9.4 million$9,377,757 | 15,786.4% |
| 35 | The Susan Thompson Buffett Foundation | NE | 2025 | $1.5 billion$1,460,871,411 | 417 | $2.7 billion$2,723,259,744 | 53.6% |
| 36 | Mass General Brigham Incorporated and Affiliates Group RTN | MA | 2024 | $1.4 billion$1,429,056,612 | not itemized | $32.2 billion$32,196,538,053 | 4.4% |
| 37 | Bayer US Patient Assistance Foundation | NJ | 2025 | $1.4 billion$1,426,030,870 | 1 | $401.4 million$401,381,199 | 355.3% |
| 38 | The Mastercard Foundation | not reported | 2024 | $1.4 billion$1,410,232,855 | not itemized | $50.3 billion$50,320,893,084 | 2.8% |
| 39 | Big Ten Conference Inc | IL | 2024 | $1.4 billion$1,373,005,505 | not itemized | $280.7 million$280,734,650 | 489.1% |
| 40 | Johns Hopkins University | MD | 2024 | $1.3 billion$1,346,182,000 | not itemized | $25.3 billion$25,294,054,000 | 5.3% |
| 41 | American Endowment Foundation | OH | 2024 | $1.3 billion$1,305,303,631 | not itemized | $8.4 billion$8,410,336,989 | 15.5% |
| 42 | Map International | GA | 2024 | $1.3 billion$1,265,212,554 | not itemized | $363.7 million$363,727,957 | 347.8% |
| 43 | The Chicago Community Trust | IL | 2024 | $1.2 billion$1,225,337,518 | not itemized | $7.1 billion$7,126,827,178 | 17.2% |
| 44 | Novo Nordisk Fonden | not reported | 2024 | $1.2 billion$1,171,517,714 | not itemized | $8.6 billion$8,588,465,835 | 13.6% |
| 45 | World Federation of Hemophilia USA | NY | 2024 | $1.2 billion$1,154,048,112 | not itemized | $377.6 million$377,644,851 | 305.6% |
| 46 | Inland Counties Regional Center Inc | CA | 2024 | $1.2 billion$1,150,197,343 | not itemized | $355.5 million$355,487,535 | 323.6% |
| 47 | University of Southern California | CA | 2024 | $1.1 billion$1,113,341,721 | not itemized | $17.0 billion$16,956,079,936 | 6.6% |
| 48 | World Vision | WA | 2024 | $1.1 billion$1,113,101,224 | not itemized | $515.3 million$515,283,132 | 216.0% |
| 49 | President and Fellows of Harvard College | MA | 2024 | $1.1 billion$1,089,639,465 | not itemized | $79.9 billion$79,935,301,000 | 1.4% |
| 50 | North Los Angeles County Regional Center Inc | CA | 2024 | $1.1 billion$1,066,126,012 | not itemized | $302.5 million$302,518,481 | 352.4% |
| 51 | New York University | NY | 2024 | $1.1 billion$1,057,746,164 | not itemized | $23.6 billion$23,589,633,382 | 4.5% |
| 52 | Jewish Communal Fund | NY | 2024 | $1.0 billion$1,023,406,196 | not itemized | $3.6 billion$3,552,406,570 | 28.8% |
| 53 | Bloomberg Family Foundation Inc | NY | 2024 | $1.0 billion$1,016,737,000 | 203 | $12.1 billion$12,117,236,821 | 8.4% |
| 54 | Trustees of Columbia University | NY | 2024 | $996.0 million$996,042,617 | not itemized | $26.0 billion$26,028,368,945 | 3.8% |
| 55 | Charities Aid Foundation America | VA | 2024 | $993.2 million$993,190,177 | not itemized | $485.8 million$485,759,064 | 204.5% |
| 56 | Regional Center of the East Bay Inc | CA | 2024 | $975.2 million$975,200,452 | not itemized | $442.9 million$442,912,028 | 220.2% |
| 57 | Bank of America Charitable Gift Fund | MA | 2024 | $969.5 million$969,496,994 | not itemized | $5.1 billion$5,096,006,595 | 19.0% |
| 58 | Trustees of Boston University | MA | 2024 | $938.6 million$938,613,847 | not itemized | $9.3 billion$9,263,866,015 | 10.1% |
| 59 | Cornell University | NY | 2024 | $925.4 million$925,439,427 | not itemized | $19.8 billion$19,796,267,550 | 4.7% |
| 60 | Navigate Affordable Housing Partners Inc | AL | 2024 | $890.1 million$890,111,727 | not itemized | $93.2 million$93,225,339 | 954.8% |
| 61 | The Board of Trustees of the Leland Stanford Junior University | CA | 2024 | $887.7 million$887,704,139 | not itemized | $68.7 billion$68,719,825,443 | 1.3% |
| 62 | San Diego Imperial Counties Developmental Services Inc | CA | 2024 | $883.4 million$883,401,853 | not itemized | $177.8 million$177,820,991 | 496.8% |
| 63 | Pivotal Philanthropies Foundation | WA | 2024 | $874.6 million$874,621,851 | 132 | $7.4 billion$7,358,421,363 | 11.9% |
| 64 | Alta California Regional Center Inc | CA | 2024 | $870.5 million$870,508,549 | not itemized | $405.3 million$405,331,078 | 214.8% |
| 65 | San Andreas Regional Center | CA | 2024 | $862.7 million$862,684,645 | not itemized | $176.5 million$176,468,872 | 488.9% |
| 66 | Yale University | CT | 2024 | $861.2 million$861,177,007 | not itemized | $58.9 billion$58,926,726,383 | 1.5% |
| 67 | Glaxosmithkline Patient Access Programs Foundation | PA | 2025 | $842.9 million$842,945,879 | 1 | $70.2 million$70,245,490 | 1,200.0% |
| 68 | Regional Center of Orange County | CA | 2024 | $807.2 million$807,220,538 | not itemized | $139.4 million$139,411,230 | 579.0% |
| 69 | Foundation for the Carolinas | NC | 2024 | $804.5 million$804,486,974 | not itemized | $3.9 billion$3,934,238,899 | 20.4% |
| 70 | Paypal Charitable Giving Fund | DC | 2024 | $797.9 million$797,890,089 | not itemized | $106.3 million$106,256,109 | 750.9% |
| 71 | University of Miami | FL | 2024 | $791.4 million$791,373,249 | not itemized | $8.9 billion$8,896,386,052 | 8.9% |
| 72 | Step Up for Students - Florida Inc | FL | 2024 | $790.2 million$790,233,792 | not itemized | $1.7 billion$1,727,462,650 | 45.7% |
| 73 | University of Chicago | IL | 2024 | $789.3 million$789,348,850 | not itemized | $15.8 billion$15,809,478,980 | 5.0% |
| 74 | Florida Clinical Practice Association Inc | FL | 2024 | $784.4 million$784,444,952 | not itemized | $385.8 million$385,750,115 | 203.4% |
| 75 | Volkswagen-Stiftung | UT | 2024 | $782.2 million$782,154,988 | 1 | $4.9 billion$4,939,258,668 | 15.8% |
| 76 | Northwestern University | IL | 2024 | $780.3 million$780,323,456 | not itemized | $20.8 billion$20,789,227,097 | 3.8% |
| 77 | Global Health Solutions Inc | GA | 2024 | $772.0 million$772,045,614 | not itemized | $0$0 | not applicable |
| 78 | Renaissance Charitable Foundation Inc | IN | 2024 | $770.8 million$770,759,425 | not itemized | $5.9 billion$5,913,566,776 | 13.0% |
| 79 | Ford Foundation | NY | 2024 | $770.7 million$770,674,415 | 4,007 | $17.5 billion$17,484,692,219 | 4.4% |
| 80 | Atlantic Coast Conference | NC | 2024 | $736.9 million$736,932,636 | not itemized | $364.4 million$364,439,570 | 202.2% |
| 81 | BNY Mellon Charitable Gift Fund | MA | 2024 | $725.6 million$725,628,666 | not itemized | $2.0 million$1,963,215 | 36,961.2% |
| 82 | Massachusetts Institute of Technology | MA | 2024 | $706.6 million$706,619,000 | not itemized | $45.3 billion$45,313,517,000 | 1.6% |
| 83 | Howard G Buffett Foundation | IL | 2025 | $698.7 million$698,710,460 | 1 | $718.1 million$718,146,804 | 97.3% |
| 84 | Northeastern University | MA | 2024 | $689.3 million$689,252,558 | not itemized | $6.8 billion$6,830,808,000 | 10.1% |
| 85 | Sergey Brin Family Foundation | CA | 2024 | $688.7 million$688,727,682 | 170 | $4.3 billion$4,309,591,153 | 16.0% |
| 86 | Trustees of the University of Pennsylvania | PA | 2024 | $675.6 million$675,616,764 | not itemized | $36.7 billion$36,736,678,000 | 1.8% |
| 87 | South Central L A Reg Central for Dvlopmntly Disabled Persons Inc | CA | 2024 | $674.4 million$674,429,171 | not itemized | $441.5 million$441,517,633 | 152.8% |
| 88 | Central Valley Regional Center Inc | CA | 2024 | $668.2 million$668,238,138 | not itemized | $360.3 million$360,302,282 | 185.5% |
| 89 | Robert Wood Johnson Foundation | NJ | 2024 | $660.7 million$660,732,627 | 3,093 | $13.4 billion$13,417,636,452 | 4.9% |
| 90 | Washington University | MO | 2024 | $650.6 million$650,637,135 | not itemized | $22.3 billion$22,330,732,000 | 2.9% |
| 91 | Save the Children Federation Inc | CT | 2024 | $632.7 million$632,693,214 | not itemized | $548.8 million$548,769,907 | 115.3% |
| 92 | William & Flora Hewlett Foundation | CA | 2024 | $625.0 million$625,041,978 | 2,001 | $14.2 billion$14,202,751,280 | 4.4% |
| 93 | Princeton University | NJ | 2024 | $620.3 million$620,310,685 | not itemized | $45.9 billion$45,858,792,000 | 1.4% |
| 94 | National Collegiate Athletic Association | IN | 2024 | $618.4 million$618,448,491 | not itemized | $1.1 billion$1,128,327,634 | 54.8% |
| 95 | Medecins Sans Frontieres USA Inc | NY | 2024 | $616.1 million$616,057,744 | not itemized | $434.3 million$434,345,054 | 141.8% |
| 96 | Mayo Clinic | MN | 2024 | $607.4 million$607,369,592 | not itemized | $26.7 billion$26,682,635,058 | 2.3% |
| 97 | Golden Gate Regional Center Inc | CA | 2024 | $597.3 million$597,303,877 | not itemized | $297.0 million$297,013,712 | 201.1% |
| 98 | Impactassets Inc | MD | 2024 | $592.0 million$591,997,031 | not itemized | $3.0 billion$3,002,686,264 | 19.7% |
| 99 | Emory University | GA | 2024 | $586.2 million$586,214,166 | not itemized | $24.9 billion$24,888,450,281 | 2.4% |
| 100 | Tri-Counties Association for the Developmentally Disabled Inc | CA | 2024 | $580.2 million$580,187,577 | not itemized | $105.3 million$105,258,549 | 551.2% |